TY  - JOUR
A1  - Quandt, Jasmin
A1  - Muik, Alexander
A1  - Salisch, Nadine Christina
A1  - Lui, Bonny Gaby
A1  - Lutz, Sebastian
A1  - Krüger, Kimberly
A1  - Wallisch, Ann-Kathrin
A1  - Adams-Quack, Petra
A1  - Bacher, Maren
A1  - Finlayson, Andrew
A1  - Ozhelvaci, Orkun
A1  - Vogler, Isabel
A1  - Grikscheit, Katharina
A1  - Hoehl, Sebastian
A1  - Götsch, Udo
A1  - Ciesek, Sandra
A1  - Türeci, Özlem
A1  - Sahin, Ugur
T1  - Omicron BA.1 breakthrough infection drives cross-variant neutralization and memory B cell formation against conserved epitopes
T2  - Science Immunology
N2  - Omicron is the evolutionarily most distinct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) to date. We report that Omicron BA.1 breakthrough infection in BNT162b2-vaccinated individuals resulted in strong neutralizing activity against Omicron BA.1, BA.2, and previous SARS-CoV-2 VOCs but not against the Omicron sublineages BA.4 and BA.5. BA.1 breakthrough infection induced a robust recall response, primarily expanding memory B (BMEM) cells against epitopes shared broadly among variants, rather than inducing BA.1-specific B cells. The vaccination-imprinted BMEM cell pool had sufficient plasticity to be remodeled by heterologous SARS-CoV-2 spike glycoprotein exposure. Whereas selective amplification of BMEM cells recognizing shared epitopes allows for effective neutralization of most variants that evade previously established immunity, susceptibility to escape by variants that acquire alterations at hitherto conserved sites may be heightened.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/70477
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-704777
SN  - 2470-9468
VL  - 7
IS  - 75, eabq2427
PB  - American Association for the Advancement of Science
CY  - Washington, DC
ER  -