TY  - JOUR
A1  - Shalamova, Lyudmila
A1  - Felgenhauer, Ulrike
A1  - Wilhelm, Jochen
A1  - Schaubmar, Andreas R.
A1  - Büttner, Kathrin
A1  - Schoen, Andreas
A1  - Widera, Marek
A1  - Ciesek, Sandra
A1  - Weber, Friedemann
T1  - Omicron variant of SARS-CoV-2 exhibits an increased resilience to the antiviral type I interferon response
T2  - PNAS Nexus
N2  - The new variant of concern (VOC) of SARS-CoV-2, Omicron (B.1.1.529), is genetically very different from other VOCs. We compared Omicron with the preceding VOC Delta (B.1.617.2) and the wildtype (wt) strain (B.1) with respect to their interactions with the antiviral interferon (IFN-alpha/beta) response in infected cells. Our data indicate that IFN induction by Omicron is low and comparable to the wt, whereas Delta showed an increased IFN induction. However, Omicron exceeded both the wt and the Delta strain with respect to the ability to withstand the antiviral state imposed by IFN-alpha.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - Omicron variant BA.1
KW  - interferon induction
KW  - interferon sensitivity
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73313
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-733131
SN  - 2752-6542
VL  - 1
IS  - 2, pgac067
SP  - 1
EP  - 4
PB  - Oxford University Press
CY  - Oxford
ER  -