TY  - JOUR
A1  - Rheinwalt, Karl Peter
A1  - Drebber, Uta
A1  - Schierwagen, Robert
A1  - Klein, Sabine
A1  - Neumann, Ulf Peter
A1  - Ulmer, Tom Florian
A1  - Plamper, Andreas
A1  - Kroh, Andreas
A1  - Schipper, Sandra
A1  - Odenthal, Margarete
A1  - Uschner, Frank Erhard
A1  - Lingohr, Philipp
A1  - Trebicka, Jonel
A1  - Brol, Maximilian
T1  - Baseline presence of NAFLD predicts weight loss after gastric bypass surgery for morbid obesity
T2  - Journal of clinical medicine
N2  - Background. Bariatric surgery is a widely used treatment for morbid obesity. Prediction of postoperative weight loss currently relies on prediction models, which mostly overestimate patients’ weight loss. Data about the influence of Non-alcoholic fatty liver disease (NAFLD) on early postoperative weight loss are scarce. Methods. This prospective, single-center cohort study included 143 patients receiving laparoscopic gastric bypass surgery (One Anastomosis-Mini Gastric Bypass (OAGB-MGB) or Roux-en-Y Gastric Bypass (RYGB)). Liver biopsies were acquired at surgery. NAFLD activity score (NAS) assigned patients to “No NAFLD”, “NAFL” or “NASH”. Follow up data were collected at 3, 6 and 12 months. Results. In total, 49.7% of patients had NASH, while 41.3% had NAFL. Compared with the No NAFLD group, NAFL and NASH showed higher body-mass-index (BMI) at follow-up (6 months: 31.0 kg/m2 vs. 36.8 kg/m2 and 36.1 kg/m2, 12 months: 27.0 kg/m2 vs. 34.4 and 32.8 kg/m2) and lower percentage of total body weight loss (%TBWL): (6 months: 27.1% vs. 23.3% and 24.4%; 12 months: 38.5% vs. 30.1 and 32.6%). Linear regression of NAS points significantly predicts percentage of excessive weight loss (%EWL) after 6 months (Cologne-weight-loss-prediction-score). Conclusions. Histopathological presence of NAFLD might lead to inferior postoperative weight reduction after gastric bypass surgery. The mechanisms underlying this observation should be further studied.
KW  - Roux-en-Y gastric bypass
KW  - one anastomosis gastric bypass
KW  - mini gastric bypass
KW  - NAFLD
KW  - NASH
KW  - weight loss
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56838
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-568381
SN  - 2077-0383
VL  - 9
IS  - 3430
PB  - MDPI
CY  - Basel
ER  -