TY  - JOUR
A1  - Schmid, Tobias
A1  - Brüne, Bernhard
T1  - Prostanoids and resolution of inflammation – beyond the lipid-mediator class switch
T2  - Frontiers in immunology
N2  - Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein, early pro-inflammatory phases are characterized and regulated by prostanoids and leukotrienes, whereas specialized pro-resolving mediators (SPM), including lipoxins, resolvins, protectins, and maresins, dominate during the resolution phase. While pro-inflammatory properties of prostanoids have been studied extensively, their impact on later phases of the inflammatory process has been attributed mainly to their ability to initiate the lipid-mediator class switch towards SPM. Yet, there is accumulating evidence that prostanoids directly contribute to the resolution of inflammation and return to homeostasis. In this mini review, we summarize the current knowledge of the resolution-regulatory properties of prostanoids and discuss potential implications for anti-inflammatory, prostanoid-targeted therapeutic interventions.
KW  - prostaglandin
KW  - prostacyclin
KW  - thromboxane
KW  - specialized pro-resolving mediator
KW  - inflammation
KW  - resolution
KW  - macrophage
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61832
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-618324
SN  - 1664-3224
VL  - 12
IS  - art. 714042
SP  - 1
EP  - 9
PB  - Frontiers Media
CY  - Lausanne
ER  -