TY  - JOUR
A1  - Vasilikos, Ioannis
A1  - Rölz, Roland
A1  - Scholz, Christoph
A1  - Mizaikoff, Boris
A1  - Argiti, Katerina
A1  - Ralf, Watzlawick
A1  - Giagkos, Georgios-Christos
A1  - Fragkakis, Evangelos M.
A1  - Ghanaati, Shahram Michael
A1  - Beck, Jürgen
A1  - Hubbe, Ulrich
T1  - Autologous platelet-rich fibrin (PRF) augmentation as an add-on therapy in deep surgical site infections (dSSIs) after instrumented spinal surgery: preliminary results of a single institution case series
T2  - Acta neurochirurgica
N2  - Background: Deep surgical site infections (dSSIs) after instrumented spinal surgery pose major therapeutic challenges. Standard treatment involves surgical debridement, wound drainage, and long-term antibiotic administration. Autologous platelet-rich fibrin (PRF) constitutes a biomaterial obtained from patients’ own blood that contains leukocytes, chemokines and growth factors boosting cicatrization. Due to favorable results reported from other surgical disciplines such as dentistry, orthopedics, maxillofacial and plastic surgery using PRF, the authors hypothesized that PRF augmentation will promote wound healing in dSSIs. Objective: To report our preliminary results on the safety and efficacy of autologous-PRF as an add-on therapy on a pilot case series of persistent dSSI after instrumented spinal surgery. Methods: Among the 293 patients who underwent dorsal decompression and stabilization of the cervical, thoracic, and lumbar spine due to degenerative diseases in our department, 12 patients (4%) presented persisting dSSI after standard wound debridement and antibiotic treatment. PRF augmentation was used during a second surgical revision as an add-on therapy to standard debridement. In all cases, the wound was primarily closed without drains. Results: Wound healing was completed between 14 and 21 days after the second surgical revision in all patients. At a median follow-up of 8 months (range: 6 to 18 months), no recurrence of dSSI nor complications were encountered in any case. Conclusions: Our preliminary results suggest that PRF augmentation in persistent dSSI after instrumented spinal surgery appears to be a safe and effective strategy to promote wound healing. Prospective controlled studies are required to define the efficiency of PRF more clearly in both treating and preventing dSSI.
KW  - Surgical site infection
KW  - Spinal surgery
KW  - Platelet-rich fibrin
KW  - Autologous biomaterial
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63566
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635669
SN  - 0942-0940
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 163
SP  - 2761
EP  - 2767
PB  - Springer
CY  - Wien [u.a.]
ER  -