TY  - JOUR
A1  - Geßler, Florian
A1  - Schmitz, Ann Kristin
A1  - Dubinski, Daniel
A1  - Bernstock, Joshua D.
A1  - Lehmann, Felix
A1  - Won, Sae-Yeon
A1  - Wittstock, Matthias
A1  - Güresir, Erdem Özer
A1  - Hadjiathanasiou, Alexis
A1  - Zimmermann, Julian
A1  - Miesbach, Wolfgang
A1  - Freiman, Thomas Michael
A1  - Vatter, Hartmut
A1  - Schuß, Patrick
T1  - Neurosurgical considerations regarding decompressive craniectomy for intracerebral hemorrhage after SARS-CoV-2-vaccination in vaccine induced thrombotic thrombocytopenia-VITT
T2  - Journal of Clinical Medicine
N2  - Given the ongoing global SARS-CoV-2-vaccination efforts, clinical awareness needs to be raised regarding the possibility of an increased incidence of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia in patients with intracerebral hemorrhage (ICH) secondary to cerebral sinus and vein thrombosis (CVT) requiring (emergency) neurosurgical treatment in the context of vaccine-induced immune thrombotic thrombocytopenia (VITT). Only recently, an association of vaccinations and cerebral sinus and vein thrombosis has been described. In a number of cases, neurosurgical treatment is warranted for these patients and special considerations are warranted when addressing the perioperative coagulation. We, herein, describe the past management of patients with VITT and established a literature-guided algorithm for the treatment of patients when addressing the impaired coagulation in these patients. Increasing insights addressing the pathophysiology of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia guide physicians in developing an interdisciplinary algorithm taking into account the special considerations of this disease.
KW  - cerebral sinus and vein thrombosis (CVT)
KW  - decompressive craniectomy
KW  - intracerebral hemorrhage (ICH)
KW  - Covid-19
KW  - vaccination
KW  - SARS-CoV-2
KW  - vaccine-induced immune thrombotic thrombocytopenia (VITT)
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62167
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-621670
SN  - 2077-0383
VL  - 10
IS  - 13, art. 2777
SP  - 1
EP  - 8
PB  - MDPI
CY  - Basel
ER  -