TY  - INPR
A1  - Grau, Jan
A1  - Schmidt, Florian
A1  - Schulz, Marcel Holger
T1  - Widespread effects of DNA methylation and intra-motif dependencies revealed by novel transcription factor binding models
T2  - bioRxiv
N2  - Several studies suggested that transcription factor (TF) binding to DNA may be impaired or enhanced by DNA methylation. We present MeDeMo, a toolbox for TF motif analysis that combines information about DNA methylation with models capturing intra-motif dependencies. In a large-scale study using ChIP-seq data for 335 TFs, we identify novel TFs that are affected by DNA methylation. Overall, we find that CpG methylation decreases the likelihood of binding for the majority of TFs. For a considerable subset of TFs, we show that intra-motif dependencies are pivotal for accurately modelling the impact of DNA methylation on TF binding.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72835
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-728354
IS  - 2020.10.21.348193
ER  -