TY  - JOUR
A1  - Schwarz, Frank
A1  - John, Gordon
A1  - Becker, Jürgen
A1  - Grötz, Knut Achim
A1  - Sader, Robert Alexander
A1  - Mihatovic, Ilja
T1  - Influence of ridge preservation procedures on extraction socket healing under antiresorptive therapy: An experimental study in rabbits
T2  - Clinical implant dentistry and related research
N2  - Background: To assess the influence of ridge preservation procedures on the healing of extraction sockets under antiresorptive therapy.
Material and Methods: A total of 10 Dutch Belted rabbits were randomly allocated to either the intravenous administration of amino‐bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (no Za [nZa]) (n = 5). At 6 months, the mandibular and maxillary molars were extracted and the four experimental sites randomly allocated to the following subgroups: (a) socket grafting using a collagen‐coated natural bone mineral (BOC) + primary wound closure, (b) coronectomy (CO), or (c) spontaneous healing + primary wound closure (SP). Za medication was continued for another 4 months. Histomorphometrical analyses considered, for example, crestal hard tissue closure of the extraction site (C) and mineralized tissue (MT) formation.
Results: Za‐SP was associated with an incomplete median C (31.76% vs 100% in nZa‐SP) and signs of bone arrosion along the confines of the socket. BOC had no major effects on increases in C and MT values in the Za group. CO commonly resulted in an encapsulation and partial replacement resorption of residual roots by MT without any histological signs of osteonecrosis.
Conclusions: (a) Za‐SP was commonly associated with a compromised socket healing and signs of osteonecrosis, (b) BOC had no major effect on socket healing in the Za group, and (c) CO at noninfected teeth might be a feasible measure for the prevention of a Za‐related osteonecrosis of the jaw.
KW  - animal experiment
KW  - antiresorptive agents
KW  - extraction socket healing
KW  - histological technic
KW  - ridge preservation
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56467
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-564673
SN  - 1708-8208
SN  - 1523-0899
VL  - 22
IS  - 4
SP  - 477
EP  - 485
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -