TY  - JOUR
A1  - Abedin, Nada
A1  - Seemann, Teresa
A1  - Kleinfeld, Sandra
A1  - Rührup, Jessica
A1  - Röseler, Stefani
A1  - Trautwein, Christian
A1  - Streetz, Konrad
A1  - Sellge, Gernot
T1  - Fecal eosinophil cationic protein is a diagnostic and predictive biomarker in young adults with inflammatory bowel disease
T2  - Journal of Clinical Medicine
N2  - Background and Aims: Fecal biomarkers are important non-invasive markers monitoring disease activity in inflammatory bowel disease (IBD). We compared the significance of fecal eosinophil cationic protein (fECP) and fecal calprotectin (fCal).
Methods: fECP and fCal were measured in patients with Crohn's disease (CD, n = 97), ulcerative colitis (UC, n = 53), Clostridioides difficile infection (CDI, n = 9), primary food allergy (PFA, n = 11), pollen-associated food allergy (n = 25) and non-inflammatory controls (n = 78). Results were correlated with clinical and endoscopic IBD activity scores.
Results: fECP was significantly elevated in CD, UC, CDI and PFA compared to controls. fCal was significantly increased in CD, UC and CDI. fECP had lower diagnostic accuracy than fCal (area under the curve (AUC) = 0.88) in differentiating between endoscopically active and inactive patients with IBD (AUC = 0.77, ROC analysis). In contrast to fCal, fECP correlated negatively with age and levels were also elevated in clinically and endoscopically inactive patients with IBD <45 years (endoscopically inactive IBD vs controls; AUC for fECP = 0.86; AUC for fCal = 0.62). However, in those patients with low inflammatory activity (fCal <250 mg/kg), high fECP indicated the need for treatment modification or surgery (fECP <200 µg/kg = 22%; 200–600 µg/kg = 44%; >600 µg/kg = 82%) at month 48 of follow-up.
Conclusions: fECP is a diagnostic and prognostic marker in young patients with IBD in remission.
KW  - inflammatory bowel disease
KW  - biomarker
KW  - calprotectin
KW  - eosinophils
KW  - eosinophil cationic protein
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51822
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-518225
SN  - 2077-0383
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
VL  - 8
IS  - 12, Art. 2025
SP  - 1
EP  - 17
PB  - MDPI
CY  - Basel
ER  -