TY  - JOUR
A1  - Salinas-Hernández, Ximena I.
A1  - Duvarci, Sevil
T1  - Dopamine in fear extinction
T2  - Frontiers in synaptic neuroscience
N2  - The ability to extinguish fear memories when threats are no longer present is critical for adaptive behavior. Fear extinction represents a new learning process that eventually leads to the formation of extinction memories. Understanding the neural basis of fear extinction has considerable clinical significance as deficits in extinction learning are the hallmark of human anxiety disorders. In recent years, the dopamine (DA) system has emerged as one of the key regulators of fear extinction. In this review article, we highlight recent advances that have demonstrated the crucial role DA plays in mediating different phases of fear extinction. Emerging concepts and outstanding questions for future research are also discussed.
KW  - dopamine
KW  - fear extinction
KW  - amygdala
KW  - medial prefrontal cortex
KW  - nucleus accumbens
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62453
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-624536
SN  - 1663-3563
N1  - This work was supported by the Deutsche Forschungsgemeinschaft [DFG SFB1193 Grants INST247/852-1 and INST 247/858-1 (subprojects B01 and C02) to SD].
VL  - 13
IS  - art. 635879
SP  - 1
EP  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -