TY  - JOUR
A1  - Fulda, Simone
T1  - Shifting the balance of mitochondrial apoptosis: therapeutic perspectives
T2  - Frontiers in oncology
N2  - Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical signal transduction cascades that control the regulation of cell death. This pathway is typically altered in human cancers, thereby providing a suitable target for therapeutic intervention. Members of the Bcl-2 family of proteins as well as cell survival signaling cascades such as the PI3K/Akt/mTOR pathway are involved in the regulation of mitochondria-mediated apoptosis. Therefore, further insights into the molecular mechanisms that form the basis for the control of mitochondria-mediated apoptosis will likely open new perspectives to bypass evasion of apoptosis and treatment resistance in human cancers.
KW  - mitochondria
KW  - apoptosis
KW  - cancer
KW  - PI3K
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28623
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-286237
SN  - 2234-943X
N1  - Copyright © 2012 Fulda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
VL  - 2
IS  - Article 121
PB  - Frontiers Media
CY  - Lausanne
ER  -