TY  - JOUR
A1  - Lange, Christian
A1  - Bibert, Stephanie
A1  - Kutalik, Zoltán
A1  - Burgisser, Philippe
A1  - Cerny, Andreas
A1  - Dufour, Jean-Francois
A1  - Geier, Andreas
A1  - Gerlach, Tilman J.
A1  - Heim, Markus H.
A1  - Malinverni, Raffaele
A1  - Negro, Francesco
A1  - Regenass, Stephan
A1  - Badenhoop, Klaus
A1  - Bojunga, Jörg
A1  - Sarrazin, Christoph
A1  - Zeuzem, Stefan
A1  - Müller, Tobias
A1  - Berg, Thomas
A1  - Bochud, Pierre-Yves
A1  - Moradpour, Darius
T1  - A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C
T2  - PLoS One
N2  - Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.

Methodology/Principal Findings: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3<20 ng/mL) during all seasons, but 25(OH)D3 serum levels were not associated with treatment outcome.

Conclusions/Significance: Our study suggests a role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D3 is not a suitable predictor of treatment outcome.
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25765
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-257656
SN  - 1932-6203
VL  - 7
IS  - (7):e40159
PB  - PLoS
CY  - Lawrence, Kan.
ER  -