TY  - JOUR
A1  - Wellens, Hein J. J.
A1  - Schwartz, Peter J.
A1  - Lindemans, Fred W.
A1  - Buxton, Alfred E.
A1  - Goldberger, Jeffrey J.
A1  - Hohnloser, Stefan H.
A1  - Huikuri, Heikki V.
A1  - Kääb, Stefan
A1  - La Rovere, Maria Teresa
A1  - Malik, Marek
A1  - Myerburg, Robert J.
A1  - Simoons, Maarten L.
A1  - Swedberg, Karl
A1  - Tijssen, Jan
A1  - Voors, Adriaan A.
A1  - Wilde, Arthur A.
T1  - Risk stratification for sudden cardiac death : current status and challenges for the future
T2  - European heart journal
N2  - Sudden cardiac death (SCD) remains a daunting problem. It is a major public health issue for several reasons: from its prevalence (20% of total mortality in the industrialized world) to the devastating psycho-social impact on society and on the families of victims often still in their prime, and it represents a challenge for medicine, and especially for cardiology. This text summarizes the discussions and opinions of a group of investigators with a long-standing interest in this field. We addressed the occurrence of SCD in individuals apparently healthy, in patients with heart disease and mild or severe cardiac dysfunction, and in those with genetically based arrhythmic diseases. Recognizing the need for more accurate registries of the global and regional distribution of SCD in these different categories, we focused on the assessment of risk for SCD in these four groups, looking at the significance of alterations in cardiac function, of signs of electrical instability identified by ECG abnormalities or by autonomic tests, and of the progressive impact of genetic screening. Special attention was given to the identification of areas of research more or less likely to provide useful information, and thereby more or less suitable for the investment of time and of research funds.
KW  - Sudden cardiac death
KW  - Risk stratification
KW  - Electrical instability
KW  - Autonomic nervous system
KW  - Cardiac function
KW  - Genetics
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/37177
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-371777
SN  - 1522-9645
SN  - 0195-668X
N1  - Copyright © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
VL  - 35
IS  - 25
SP  - 1642
EP  - 1651
PB  - Oxford Univ. Press
CY  - Oxford
ER  -