TY  - JOUR
A1  - Koch, Agnes Antonia Sophie
A1  - Sponholz, Stefan
A1  - Trainer, Stephan
A1  - Stratmann, Jan Alexander
A1  - Sebastian, Martin
A1  - Rauch, Maximilian
A1  - Wolff, Robert
A1  - Steinbach, Joachim Peter
A1  - Ronellenfitsch, Michael Wilfried
A1  - Urban, Hans
T1  - Pulmonary resection after radiosurgery and neoadjuvant immunochemotherapy for NSCLC patients with synchronous brain metastasis — a case series of three patients
T2  - Current oncology
N2  - Brain metastases are a common finding upon initial diagnosis of otherwise locally limited non-small cell lung cancer. We present a retrospective case series describing three cases of patients with symptomatic, synchronous brain metastases and resectable lung tumors. The patients received local ablative treatment of the brain metastases followed by neoadjuvant immunochemotherapy with pemetrexed, cisplatin, and pembrolizumab. Afterwards, resection of the pulmonary lesion with curative intent was performed. One patient showed progressive disease 12 months after initial diagnosis, and passed away 31 months after initial diagnosis. Two of the patients are still alive and maintain a good quality of life with a progression-free survival and overall survival of 28 and 35 months, respectively, illustrating the potential of novel combinatorial treatment approaches.
KW  - neoadjuvant immunochemotherapy
KW  - NSCLC
KW  - brain metastasis
KW  - immune checkpoint inhibitors
KW  - pembrolizumab
KW  - stereotactic radiosurgery
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69297
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-692978
SN  - 1718-7729
VL  - 29
IS  - 4
SP  - 2225
EP  - 2239
PB  - Multimed
CY  - Toronto, Ontario
ER  -