TY  - JOUR
A1  - Jenei-Lanzl, Zsuzsa
A1  - Straub, Rainer H.
T1  - β2-adrenoceptors kick osteoarthritis – time to rethink prevention and therapy?
T2  - Osteoarthritis and cartilage
N2  - Although, during the past decades, substantial advances emerged in identifying major local and systemic factors contributing to initiation and progression of osteoarthritis (OA), some neuroendocrine mechanisms are still not understood or even neglected when thinking about novel therapeutic options. One of which is the sympathetic nervous system that exhibits various OA-promoting effects in different tissues of the joint. Interestingly, the β2-adrenoceptor (AR) mediates the majority of these effects as demonstrated by several in vitro, in vivo as well as in clinical studies. This review article does not only summarize studies of the past two decades demonstrating that the β2-AR plays an OA-promoting role in different tissues of the joint but also aims to encourage the reader to think about next-level research to discover novel and innovative preventive and/or therapeutic strategies targeting the β2-AR in OA.
KW  - osteoarthritis
KW  - sympathetic nervous system
KW  - β2-adrenoceptor
KW  - adrenergic therapy
Y1  - 2024
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/86110
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-861102
SN  - 1063-4584
VL  - 2024
IS  - In Press, Journal Pre-proof
PB  - Elsevier
CY  - Amsterdam
ER  -