TY  - JOUR
A1  - Wijngaarden, Joeri B. G. van
A1  - Babl, Susanne
A1  - Ito, Hiroshi T.
T1  - Entorhinal-retrosplenial circuits for allocentric-egocentric transformation of boundary coding
T2  - eLife
N2  - Spatial navigation requires landmark coding from two perspectives, relying on viewpoint-invariant and self-referenced representations. The brain encodes information within each reference frame but their interactions and functional dependency remains unclear. Here we investigate the relationship between neurons in the rat's retrosplenial cortex (RSC) and entorhinal cortex (MEC) that increase firing near boundaries of space. Border cells in RSC specifically encode walls, but not objects, and are sensitive to the animal’s direction to nearby borders. These egocentric representations are generated independent of visual or whisker sensation but are affected by inputs from MEC that contains allocentric spatial cells. Pharmaco- and optogenetic inhibition of MEC led to a disruption of border coding in RSC, but not vice versa, indicating allocentric-to-egocentric transformation. Finally, RSC border cells fire prospective to the animal’s next motion, unlike those in MEC, revealing the MEC-RSC pathway as an extended border coding circuit that implements coordinate transformation to guide navigation behavior.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73901
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-739019
SN  - 2050-084X
VL  - 9
IS  - e59816
PB  - eLife Sciences Publications
CY  - Cambridge
ER  -