TY  - JOUR
A1  - Humke, Clara Julia
A1  - Höh, Robert Benedikt
A1  - Preißer, Felix
A1  - Wenzel, Mike
A1  - Welte, Maria-Noemi
A1  - Theißen, Lena Hermine
A1  - Bodelle, Boris
A1  - Köllermann, Jens
A1  - Steuber, Thomas
A1  - Haese, Alexander
A1  - Roos, Frederik
A1  - Kluth, Luis
A1  - Becker, Andreas
A1  - Chun, Felix
A1  - Mandel, Philipp
T1  - Concordance between preoperative mpMRI and pathological stage and its influence on nerve-sparing surgery in patients with high-risk prostate cancer
T2  - Current oncology
N2  - Background: We aimed to determine the concordance between the radiologic stage (rT), using multiparametric magnetic resonance imaging (mpMRI), and pathologic stage (pT) in patients with high-risk prostate cancer and its influence on nerve-sparing surgery compared to the use of the intraoperative frozen section technique (IFST). Methods: The concordance between rT and pT and the rates of nerve-sparing surgery and positive surgical margin were assessed for patients with high-risk prostate cancer who underwent radical prostatectomy. Results: The concordance between the rT and pT stages was shown in 66.4% (n = 77) of patients with clinical high-risk prostate cancer. The detection of patients with extraprostatic disease (≥pT3) by preoperative mpMRI showed a sensitivity, negative predictive value and accuracy of 65.1%, 51.7% and 67.5%. In addition to the suspicion of extraprostatic disease in mpMRI (≥rT3), 84.5% (n = 56) of patients with ≥rT3 underwent primary nerve-sparing surgery with IFST, resulting in 94.7% (n = 54) of men with at least unilateral nerve-sparing surgery after secondary resection with a positive surgical margin rate related to an IFST of 1.8% (n = 1). Conclusion: Patients with rT3 should not be immediately excluded from nerve-sparing surgery, as by using IFST some of these patients can safely undergo nerve-sparing surgery.
KW  - radical prostatectomy
KW  - multiparametric magnetic resonance imaging
KW  - nerve-sparing surgery
KW  - prostate cancer
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/81805
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-818051
SN  - 1718-7729
VL  - 29
IS  - 4
SP  - 2385
EP  - 2394
PB  - Multimed
CY  - Toronto, Ontario
ER  -