TY  - INPR
A1  - Lewis, Christopher Murphy
A1  - Jianguang, Ni
A1  - Wunderle, Thomas
A1  - Jendritza, Patrick
A1  - Diester, Ilka
A1  - Fries, Pascal
T1  - Gamma-rhythmic input causes spike output
T2  - bioRxiv
N2  - The gamma rhythm has been implicated in neuronal communication, but causal evidence remains indirect. We measured spike output of local neuronal networks and emulated their synaptic input through optogenetics. Opsins provide currents through somato-dendritic membranes, similar to synapses, yet under experimental control with high temporal precision. We expressed Channelrhodopsin-2 in excitatory neurons of cat visual cortex and recorded neuronal responses to light with different temporal characteristics. Sine waves of different frequencies entrained neuronal responses with a reliability that peaked for input frequencies in the gamma band. Crucially, we also presented white-noise sequences, because their temporal unpredictability enables analysis of causality. Neuronal spike output was caused specifically by the input’s gamma component. This gamma-specific transfer function is likely an emergent property of in-vivo networks with feedback inhibition. The method described here could reveal the transfer function between the input to any one and the output of any other neuronal group.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72720
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-727207
IS  - 2020.03.26.010678
ER  -