TY  - JOUR
A1  - Bucher, Andreas M.
A1  - De Cecco, Carlo N.
A1  - Schoepf, U. Joseph
A1  - Meinel, Felix G.
A1  - Krazinski, Aleksander W.
A1  - Spearman, James V.
A1  - McQuiston, Andrew D.
A1  - Wang, Rui
A1  - Bucher, Judith
A1  - Vogl, Thomas J.
A1  - Katzberg, Richard W.
T1  - Is contrast medium osmolality a causal factor for contrast-induced nephropathy?
T2  - BioMed research international
N2  - The exact pathophysiology of contrast-induced nephropathy (CIN) is not fully clarified, yet the osmotic characteristics of contrast media (CM) have been a significant focus in many investigations of CIN. Osmotic effects of CM specific to the kidney include transient decreases in blood flow, filtration fraction, and glomerular filtration rate. Potentially significant secondary effects include an osmotically induced diuresis with a concomitant dehydrating effect. Clinical experiences that have compared the occurrence of CIN between the various classes of CM based on osmolality have suggested a much less than anticipated advantage, if any, with a lower osmolality. Recent animal experiments actually suggest that induction of a mild osmotic diuresis in association with iso-osmolar agents tends to offset potentially deleterious renal effects of high viscosity-mediated intratubular CM stagnation.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/36931
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-369318
SN  - 2314-6141
SN  - 2314-6133
N1  - Copyright © 2014 Andreas M. Bucher et al. This is an open access article distributed under the Creative Commons Attribution Licensehttp://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2014
IS  - Article ID 931413
SP  - 1
EP  - 8
PB  - Hindawi
CY  - New York [u.a.]
ER  -