TY  - JOUR
A1  - Königs, Christoph
A1  - Schultze-Straßer, Stephan
A1  - Quaiser, Andrea
A1  - Bochennek, Konrad
A1  - Schwabe, Dirk
A1  - Klingebiel, Thomas
A1  - Köhl, Ulrike
A1  - Cappel, Claudia
A1  - Rolle, Udo
A1  - Bader, Peter
A1  - Bremm, Melanie
A1  - Hünecke, Sabine
A1  - Bakhtiar, Shahrzad
T1  - An exponential regression model reveals the continuous development of B cell subpopulations used as reference values in children
T2  - Frontiers in Pediatrics
N2  - B lymphocytes are key players in humoral immunity, expressing diverse surface immunoglobulin receptors directed against specific antigenic epitopes. The development and profile of distinct subpopulations have gained awareness in the setting of primary immunodeficiency disorders, primary or secondary autoimmunity and as therapeutic targets of specific antibodies in various diseases. The major B cell subpopulations in peripheral blood include naïve (CD19+ or CD20+IgD+CD27−), non-switched memory (CD19+ or CD20+IgD+CD27+) and switched memory B cells (CD19+ or CD20+IgD−CD27+). Furthermore, less common B cell subpopulations have also been described as having a role in the suppressive capacity of B cells to maintain self-tolerance. Data on reference values for B cell subpopulations are limited and only available for older age groups, neglecting the continuous process of human B cell development in children and adolescents. This study was designed to establish an exponential regression model to produce continuous reference values for main B cell subpopulations to reflect the dynamic maturation of the human immune system in healthy children.
KW  - B cell subpopulations
KW  - reference values
KW  - exponential model
KW  - autoimmunity
KW  - flow cytometry
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46550
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465500
SN  - 2296-2360
N1  - Copyright: © 2018 Königs, Schultze-Strasser, Quaiser, Bochennek, Schwabe, Klingebiel, Koehl, Cappel, Rolle, Bader, Bremm, Huenecke and Bakhtiar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 6
IS  - Art. 121
SP  - 1
EP  - 9
PB  - Frontiers Media
CY  - Lausanne
ER  -