TY  - JOUR
A1  - Koenig, Christa
A1  - Lehrnbecher, Thomas
T1  - Diagnostics and therapy of paediatric patients with febrile neutropenia
T2  - EJC Paediatric Oncology
N2  - Febrile neutropenia is a common infectious complication in children and adolescents receiving chemotherapy for cancer, requiring immediate hospitalisation and empirical antibacterial therapy. The risk for a severe infection increases with lower neutrophil counts, but other factors such as underlying malignancy, remission state or the genetic background might also impact on the risk and severity of infection. Initial antibacterial treatment as well as modification and cessation of therapy depends on clinical performance, microbiological findings and haematological recovery. Although paediatric specific guidelines have been developed in the last decade, a number of questions are still unsolved. This article gives an overview on diagnostics and management of paediatric patients presenting with febrile neutropenia, on research gaps and will speculate on future perspective.
KW  - Child
KW  - febrile neutropenia
KW  - risk group
KW  - diagnostics
KW  - antibacterial therapy
KW  - antifungal therapy
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79164
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-791643
SN  - 2772-610X
VL  - 2023
IS  - 100116, In Press, Journal Pre-proof
PB  - Elsevier
CY  - Amsterdam
ER  -