TY  - JOUR
A1  - Neill, Thomas
A1  - Schäfer, Liliana
A1  - Iozzo, Renato V.
T1  - Instructive roles of extracellular matrix on autophagy
T2  - The American Journal of Pathology
N2  - Autophagy plays an essential role in maintaining an intricate balance between nutrient demands and energetic requirements during normal homeostasis. Autophagy recycles metabolic substrates from nonspecific bulk degradation of proteins and excess or damaged organelles. Recent work posits an active and dynamic signaling role for extracellular matrix-evoked autophagic regulation, that is, allosteric and independent of prevailing nutrient conditions. Several candidates, representing a diverse repertoire of matrix constituents (decorin, collagen VI, laminin α2, endostatin, endorepellin, and kringle V), can modulate autophagic signaling pathways. Importantly, a novel principle indicates that matrix constituents can differentially modulate autophagic induction and repression via interaction with specific receptors. Most of the matrix-derived factors described here appear to control autophagy in a canonical manner but independent of nutrient deprivation. Because the molecular composition and structure of the extracellular matrix are dynamically remodeled during various physiological and pathological conditions, we propose that matrix-regulated autophagy is key for maintaining proper tissue homeostasis and disease prevention, such as cancer progression and muscular dystrophies.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77025
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-770254
SN  - 0002-9440
VL  - 184
IS  - 8
SP  - 2146
EP  - 2153
PB  - Elsevier
CY  - Amsterdam
ER  -