TY  - JOUR
A1  - Wenzel, Mike
A1  - Nocera, Luigi
A1  - Collà Ruvolo, Claudia
A1  - Würnschimmel, Christoph
A1  - Tian, Zhe
A1  - Shariat, Shahrokh F.
A1  - Saad, Fred
A1  - Briganti, Alberto
A1  - Tilki, Derya
A1  - Mandel, Philipp
A1  - Becker, Andreas
A1  - Kluth, Luis
A1  - Chun, Felix
A1  - Karakiewicz, Pierre I.
T1  - Incidence rates and contemporary trends in primary urethral cancer
T2  - Cancer Causes & Control
N2  - Purpose: We assessed contemporary incidence rates and trends of primary urethral cancer.
Methods: We identified urethral cancer patients within Surveillance, Epidemiology and End Results registry (SEER, 2004–2016). Age-standardized incidence rates per 1,000,000 (ASR) were calculated. Log linear regression analyses were used to compute average annual percent change (AAPC).
Results: From 2004 to 2016, 1907 patients with urethral cancer were diagnosed (ASR 1.69; AAPC: -0.98%, p = 0.3). ASR rates were higher in males than in females (2.70 vs. 0.55), respectively and did not change over the time (both p = 0.3). Highest incidence rates were recorded in respectively ≥75 (0.77), 55–74 (0.71) and ≤54 (0.19) years of age categories, in that order. African Americans exhibited highest incidence rate (3.33) followed by Caucasians (1.72), other race groups (1.57) and Hispanics (1.57), in that order. A significant decrease occurred over time in Hispanics, but not in other race groups. In African Americans, male and female sex-stratified incidence rates were higher than in any other race group. Urothelial histological subtype exhibited highest incidence rate (0.92), followed by squamous cell carcinoma (0.41), adenocarcinoma (0.29) and other histologies (0.20). In stage stratified analyses, T1N0M0 stage exhibited highest incidence rate. However, it decreased over time (−3.00%, p = 0.02) in favor of T1-4N1-2M0 stage (+ 2.11%, p = 0.02).
Conclusion: Urethral cancer is rare. Its incidence rates are highest in males, elderly patients, African Americans and in urothelial histological subtype. Most urethral cancer cases are T1N0M0, but over time, the incidence of T1N0M0 decreased in favor of T1-4N1-2M0.
KW  - Urethral cancer
KW  - Incidence rate
KW  - Time trend
KW  - Region
KW  - Race
KW  - Histology
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75079
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-750798
SN  - 1573-7225
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 32
IS  - 6
SP  - 627
EP  - 634
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht [u.a.]
ER  -