TY  - JOUR
A1  - Würnschimmel, Christoph
A1  - Wenzel, Mike
A1  - Chierigo, Francesco
A1  - Flammia, Rocco Simone
A1  - Tian, Zhe
A1  - Saad, Fred
A1  - Briganti, Alberto
A1  - Shariat, Shahrokh F.
A1  - Suardi, Nazareno
A1  - Terrone, Carlo
A1  - Gallucci, Michele
A1  - Chun, Felix
A1  - Tilki, Derya
A1  - Graefen, Markus
A1  - Karakiewicz, Pierre I.
T1  - External beam radiotherapy and radical prostatectomy are associated with better survival in Asian prostate cancer patients
T2  - International journal of urology
N2  - Objectives: To test the effect of race/ethnicity on cancer-specific mortality after radical prostatectomy or external beam radiotherapy in localized prostate cancer patients. Methods: In the Surveillance, Epidemiology and End Results database 2004–2016, we identified intermediate-risk and high-risk white (n = 151 632), Asian (n = 11 189), Hispanic/Latino (n = 20 077) and African American (n = 32 550) localized prostate cancer patients, treated with external beam radiotherapy or radical prostatectomy. Race/ethnicity-stratified cancer-specific mortality analyses relied on competing risks regression, after propensity score matching for patient and cancer characteristics. Results: Compared with white patients, Asian intermediate- and high-risk external beam radiotherapy patients showed lower cancer-specific mortality (hazard ratio 0.58 and 0.70, respectively, both P ≤ 0.02). Additionally, Asian high-risk radical prostatectomy patients also showed lower cancer-specific mortality than white patients (hazard ratio 0.72, P = 0.04), but not Asian intermediate-risk radical prostatectomy patients (P = 0.08). Conversely, compared with white patients, African American intermediate-risk radical prostatectomy patients showed higher cancer-specific mortality (hazard ratio 1.36, P = 0.01), but not African American high-risk radical prostatectomy or intermediate- and high-risk external beam radiotherapy patients (all P ≥ 0.2). Finally, compared with white people, no cancer-specific mortality differences were recorded for Hispanic/Latino patients after external beam radiotherapy or radical prostatectomy, in both risk levels (P ≥ 0.2). Conclusions: Relative to white patients, an important cancer-specific mortality advantage applies to intermediate-risk and high-risk Asian prostate cancer patients treated with external beam radiotherapy, and to high-risk Asian patients treated with radical prostatectomy. These observations should be considered in pretreatment risk stratification and decision-making.
KW  - cancer-specific mortality
KW  - external beam radiotherapy
KW  - localized prostate cancer
KW  - other-cause mortality
KW  - radical prostatectomy
KW  - Surveillance
KW  - Epidemiology and End Results
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62771
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-627718
SN  - 1442-2042
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 29
IS  - 1
SP  - 17
EP  - 24
PB  - Wiley-Blackwell
CY  - Oxford [u.a.]
ER  -