TY  - JOUR
A1  - Ulke, Christine
A1  - Surova, Galina
A1  - Sander, Christian
A1  - Engel, Christoph
A1  - Wirkner, Kerstin
A1  - Jawinski, Philippe
A1  - Hensch, Tilman
A1  - Hegerl, Ulrich
T1  - Fatigue in cancer and neuroinflammatory and autoimmune disease: CNS arousal matters
T2  - Brain Sciences
N2  - The term fatigue is not only used to describe a sleepy state with a lack of drive, as observed in patients with chronic physical illnesses, but also a state with an inhibition of drive and central nervous system (CNS) hyperarousal, as frequently observed in patients with major depression. An electroencephalogram (EEG)-based algorithm has been developed to objectively assess CNS arousal and to disentangle these pathophysiologically heterogeneous forms of fatigue. The aim of this study was to test the hypothesis that fatigued patients with CNS hyperarousal score higher on depressive symptoms than those without this neurophysiological pattern. Methods: Subjects with fatigue (Multidimensional Fatigue Inventory sum-score > 40) in the context of cancer, neuroinflammatory, or autoimmune diseases were drawn from the 60+ cohort of the Leipzig Research Center for Civilization Diseases. CNS arousal was assessed by automatic EEG-vigilance stage classification using the Vigilance Algorithm Leipzig (VIGALL 2.1) based on 20 min EEG recordings at rest with eyes closed. Depression was assessed by the Inventory of Depressive Symptomatology (IDS-SR). Results: Sixty participants (33 female; median age: 67.5 years) were included in the analysis. As hypothesized, fatigued patients with CNS hyperarousal had higher IDS-SR scores than those without hyperarousal (F1,58 = 18.34; p < 0.0001, η2 = 0.240). Conclusion: hyperaroused fatigue in patients with chronic physical illness may be a sign of comorbid depression.
KW  - depression
KW  - fatigue
KW  - electroencephalography
KW  - hyperarousal
KW  - neurophysiology
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56053
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-560535
SN  - 2076-3425
VL  - 10
IS  - Article 569
PB  - MDPI
CY  - Basel
ER  -