TY  - JOUR
A1  - Henke, Christian
A1  - Rieger, Johannes
A1  - Hartmann, Sylvia
A1  - Middendorp, Marcus
A1  - Steinmetz, Helmuth
A1  - Ziemann, Ulf
T1  - Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil
T2  - BMC neurology
N2  - Background: Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma.
Case presentation: Here we present the case of a 38-year old male with an over 12 months rapidly progressive cerebellar syndrome. Extensive diagnostic workup revealed selective hypermetabolism of the right tonsil in whole-body PET. Histological examination after tonsillectomy demonstrated a lymphoepithelial carcinoma of the tonsil and the tongue base strongly suggesting a paraneoplastic cause of the cerebellar syndrome. To the best of our knowledge this is the first case of an association of a lymphoepithelial carcinoma, a rare pharyngeal tumor, with PCD.
Conclusions: In cases of classical paraneoplastic syndromes an extensive search for neoplasms should be performed including whole-body PET to detect tumors early in the course of the disease.
KW  - Lymphoepithelioma
KW  - Paraneoplastic syndrome
KW  - PET
KW  - Subacute cerebellar degeneration
KW  - Tonsil
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/31879
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-318790
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016266
SN  - 1471-2377
N1  - © 2013 Henke et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 13
IS  - 147
SP  - 1
EP  - 4
PB  - BioMed Central ; Springer
CY  - London ; Berlin ; Heidelberg
ER  -