TY  - JOUR
A1  - Rodriguez Aburto, Maria
A1  - Hurlé, Juan M.
A1  - Varela-Nieto, Isabel
A1  - Magariños, Marta
T1  - Autophagy during vertebrate development
T2  - Cells : open access journal
N2  - Autophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.
KW  - autophagy
KW  - development
KW  - proliferation
KW  - apoptosis
KW  - cell differentiation
KW  - homeostasis
KW  - aging
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/30013
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-300134
SN  - 2073-4409
N1  - © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 1
IS  - 3
SP  - 428
EP  - 448
PB  - MDPI
CY  - Basel
ER  -