TY  - JOUR
A1  - Tiku, Varnesh
A1  - Tan, Man-Wah
A1  - Đikić, Ivan
T1  - Mitochondrial functions in infection and immunity
T2  - Trends in Cell Biology
N2  - Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On the other side, major host responses elicited against infections are directly dependent on mitochondrial functions, thus placing mitochondria centrally in maintaining homeostasis upon infection. In this review, we summarize how different bacteria and viruses impact morphological and functional changes in host mitochondria and how this manipulation can influence microbial pathogenesis as well as the host cell metabolism and immune responses.
KW  - mitochondrial morphology
KW  - mitochondrial metabolism
KW  - bacteria
KW  - viruses
KW  - cell death
KW  - innate immunity
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77741
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-777419
SN  - 0962-8924
VL  - 30
IS  - 4
SP  - 263
EP  - 275
PB  - Elsevier
CY  - Amsterdam
ER  -