TY  - JOUR
A1  - Lilienfeld-Toal, Marie von
A1  - Berger, Annemarie
A1  - Christopeit, Maximilian
A1  - Hentrich, Marcus
A1  - Heussel, Claus Peter
A1  - Kalkreuth, Jana
A1  - Klein, Michael
A1  - Kochanek, Matthias
A1  - Penack, Olaf
A1  - Hauf, Elke
A1  - Rieger, Christina
A1  - Silling, Gerda
A1  - Vehreschild, Maria J. G. T.
A1  - Weber, Thomas
A1  - Wolf, Hans-Heinrich
A1  - Lehners, Nicola
A1  - Schalk, Enrico
A1  - Mayer, Karin
T1  - Community acquired respiratory virus infections in cancer patients—guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology
T2  - European journal of cancer
N2  - Background: Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.
Methods: A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections including influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus and adenovirus.
Results: CRV infections in cancer patients may lead to pneumonia in approximately 30% of the cases, with an associated mortality of around 25%. For diagnosis of a CRV infection, combined nasal/throat swabs or washes/aspirates give the best results and nucleic acid amplification based-techniques (NAT) should be used to detect the pathogen. Hand hygiene, contact isolation and face masks have been shown to be of benefit as general infection management. Causal treatment can be given for influenza, using a neuraminidase inhibitor, and respiratory syncytial virus, using ribavirin in addition to intravenous immunoglobulins. Ribavirin has also been used to treat parainfluenza virus and human metapneumovirus, but data are inconclusive in this setting. Cidofovir is used to treat adenovirus pneumonitis.
Conclusions: CRV infections may pose a vital threat to patients with underlying malignancy. This guideline provides information on diagnosis and treatment to improve the outcome.
KW  - Upper respiratory tract infection
KW  - Pneumonia
KW  - Superinfection
KW  - Influenza
KW  - Respiratory syncytial virus
KW  - Parainfluenza
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45757
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-457573
SN  - 1879-0852
SN  - 1879-2995
SN  - 0959-8049
SN  - 0014-2964
N1  - © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 67
SP  - 200
EP  - 212
PB  - Elsevier
CY  - Amsterdam [u. a.]
ER  -