TY  - JOUR
A1  - Winkler, Ulrich
T1  - Über die Abhängigkeit der bakteriziden Wirkung von Mitomycin C auf E. coli B und B/MC von der Temperatur und dem Nährmedium
T2  - Zeitschrift für Naturforschung, B
N2  - The bactericidal effect of Mitomycin C on E. coli B and the partial reactivability of MC induced cell-inactivations depends on the genotype, the composition of the plating medium and the postincubation temperature in a way rather similar to that found in corresponding UV-experiments. This indicates that at least one type of MC-induced damage in E. coli must be identical or similar with lesions produced by UV.
The kinetics of MC-bindung to the cells is the same for the wildtype and an MC-resistant mutant. The temperature coefficient Q10 for binding of MC is between 2 and 4 in the range from 20 °C to 45 °C ; this shows that the MC-uptake is propably not limited by physical reasons.
The results have been discussed considering the hypothesis that MC acts by activating the cellular DNase.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69893
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-698936
SN  - 1865-7117
SN  - 0932-0776
VL  - 17
IS  - 10
SP  - 670
EP  - 675
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -