TY  - INPR
A1  - Wiesman, Alex I.
A1  - Donhauser, Peter W.
A1  - Degroot, Clotilde
A1  - Diab, Sabrina
A1  - Kousaie, Shanna
A1  - Fon, Edward A.
A1  - Klein, Denise
A1  - Baillet, Sylvain
T1  - Aberrant neurophysiological signaling underlies speech impairments in Parkinson’s disease
T2  - medRxiv
N2  - Difficulty producing intelligible speech is a common and debilitating symptom of Parkinson’s disease (PD). Yet, both the robust evaluation of speech impairments and the identification of the affected brain systems are challenging. We examine the spectral and spatial definitions of the functional neuropathology underlying reduced speech quality in patients with PD using a new approach to characterize speech impairments and a novel brain-imaging marker. We found that the interactive scoring of speech impairments in PD (N=59) is reliable across non-expert raters, and better related to the hallmark motor and cognitive impairments of PD than automatically-extracted acoustical features. By relating these speech impairment ratings to neurophysiological deviations from healthy adults (N=65), we show that articulation impairments in patients with PD are robustly predicted from aberrant activity in the left inferior frontal cortex, and that functional connectivity of this region with somatomotor cortices mediates the influence of cognitive decline on speech deficits.
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73650
IS  - 2022.04.01.22273315
ER  -