TY  - JOUR
A1  - Eckrich, Jonas
A1  - Hinkel, Julia
A1  - Fischl, Anna
A1  - Herrmann, Eva
A1  - Holtappels, Gabriele
A1  - Bachert, Claus
A1  - Zielen, Stefan
T1  - Nasal IgE in subjects with allergic and non-allergic rhinitis
T2  - World Allergy Organization journal
N2  - Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.
Methods: 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-four 24 subjects with a house dust mite allergy, 21 subjects with a non-allergic rhinitis, and 18 non-allergic controls were further investigated at visit 2. Blood samples were taken, and nasal secretion was examined. In addition, all groups performed a nasal provocation test with house dust mite (HDM).
Results: In serum and nasal secretion, total IgE and house dust mite specific IgE significantly differed between HDM positive subjects and controls. However, no differences between non-allergic subjects and control subjects were quantifiable. Neither a nasal provocation test nor a nasal IgE to HDM allergens showed a measurable positive response in any of the non-allergic rhinitis subjects as well as the healthy controls, whilst being positive in 13 subjects with HDM allergy.
Conclusions: Nasal IgE is present in subjects with HDM allergy, but not in non-allergic rhinitis. In the investigated non-selected population, exclusive local production of IgE is absent. By implication, therefore, our findings challenge the emerging concept of local allergic rhinitis.
Study identifier at ClinicalTrials.gov: NCT 02810535.
KW  - Allergic rhinitis
KW  - House dust mite allergy
KW  - Local IgE
KW  - Local allergic rhinitis
KW  - Non-allergic-rhinitis
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54738
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-547386
SN  - 1939-4551
N1  - © 2020 The Authors. Published by Elsevier Inc. on behalf of World Allergy Organization. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 13
IS  - 6, Art. 100129
SP  - 1
EP  - 12
PB  - Wolters Kluwer Health Lippincott Williams & Wilkins
CY  - Hagerstown, Md.
ER  -