TY  - JOUR
A1  - Klebes, Anna
A1  - Ates, Hatice Ceren
A1  - Verboket, René
A1  - Urban, Gerald A.
A1  - Stetten, Felix von
A1  - Dincer, Can
A1  - Früh, Susanna Maria
T1  - Emerging multianalyte biosensors for the simultaneous detection of protein and nucleic acid biomarkers
T2  - Biosensors and bioelectronics
N2  - Traditionally, biosensors are designed to detect one specific analyte. Nevertheless, disease progression is regulated in a highly interactive way by different classes of biomolecules like proteins and nucleic acids. Therefore, a more comprehensive analysis of biomarkers from a single sample is of utmost importance to further improve both, the accuracy of diagnosis as well as the therapeutic success. This review summarizes fundamentals like biorecognition and sensing strategies for the simultaneous detection of proteins and nucleic acids and discusses challenges related to multianalyte biosensor development. We present an overview of the current state of biosensors for the combined detection of protein and nucleic acid biomarkers associated with widespread diseases, among them cancer and infectious diseases. Furthermore, we outline the multianalyte analysis in the rapidly evolving field of single-cell multiomics, to stress its significance for the future discovery and validation of biomarkers. Finally, we provide a critical perspective on the performance and translation potential of multianalyte biosensors for medical diagnostics.
KW  - Multianalyte detection
KW  - Medical diagnostics
KW  - Protein biomarkers
KW  - Nucleic acid biomarkers
KW  - Biorecognition strategies
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/79479
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-794790
SN  - 0956-5663
VL  - 244.2024
IS  - 115800
PB  - Elsevier
CY  - Amsterdam
ER  -