TY  - JOUR
A1  - Radeloff, Daniel
A1  - Ciaramidaro, Angela
A1  - Siniatchkin, Michael
A1  - Hainz, Daniela
A1  - Schlitt, Sabine
A1  - Weber, Bernhard
A1  - Poustka, Fritz
A1  - Bölte, Sven
A1  - Walter, Henrik
A1  - Freitag, Christine M.
T1  - Structural alterations of the social brain : a comparison between schizophrenia and autism
T2  - PLoS One
N2  - Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in brain structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subjects were included to identify global and regional brain volume alterations. No global gray matter or white matter differences were found between groups. In regional data, patients with autism spectrum disorder compared to typically developed control subjects showed smaller gray matter volume in the amygdala, insula, and anterior medial prefrontal cortex. Compared to patients with schizophrenia, patients with autism spectrum disorder displayed smaller gray matter volume in the left insula. Disorder specific positive correlations were found between mentalizing ability and left amygdala volume in autism spectrum disorder, and hallucinatory behavior and insula volume in schizophrenia. Results suggest the involvement of social brain areas in both disorders. Further studies are needed to replicate these findings and to quantify the amount of distinct and overlapping neural correlates in autism spectrum disorder and schizophrenia.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/34489
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-344898
SN  - 1932-6203
N1  - Copyright: © 2014 Radeloff et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (9):e106539
PB  - PLoS
CY  - Lawrence, Kan.
ER  -