TY  - JOUR
A1  - Hornung, Jan‐Erik
A1  - Weinrich, Timo
A1  - Göbel, Michael
T1  - Directed crosslinking of RNA by glutathione‐triggered PNA‐quinone‐methide‐conjugates
T2  - European journal of organic chemistry
N2  - Quinone methide precursors protected with alkyldithiomethyl groups have been synthesized and converted into PNA conjugates. Stable in the absence of reducing agents, the electrophilic quinone methide is released by glutathione in concentrations typical for the cytosol. Self-alkylation then occurs or crosslinking of RNA when hybridized with complementary strands. Fastest reactions are seen for the sterically least hindered compound.
KW  - Antisense agents
KW  - Alkylation of RNA
KW  - Disulfide bond
KW  - Glutathione
KW  - Peptide nucleic acids
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78296
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-782965
SN  - 1099-0690
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 2022
IS  - 33, art. e202200318
SP  - 1
EP  - 5
PB  - Wiley-VCH Verl.
CY  - Weinheim
ER  -