TY  - JOUR
A1  - Geißler, Christin
A1  - Hambek, Markus
A1  - Eckardt, Anne Gisela
A1  - Arnoldner, Christoph
A1  - Diensthuber, Marc
A1  - Stöver, Timo
A1  - Wagenblast, Jens
T1  - The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model
T2  - Oncology reports
N2  - One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence at a later date. The recruitment of these G0-arresting cells into the active cell cycle and thus, proliferation, may increase the efficacy of chemotherapeutic agents. The aim of this study was to investigate whether stimulation with recombinant epidermal growth factor (EGF) or serotonin leads to an increased tumor cell proliferation in xenografts. Detroit 562 cells were injected into NMRI-Foxn1nu mice. Treatment was performed with 15 µg murine or human EGF, or 200 µg serotonin. The control mice were treated with Lactated Ringer's solution (5 mice/group). Tumor size was measured on days 4, 8 and 12 after tumor cell injection. The EGF stimulated mice showed a significantly higher tumor growth compared to the serotonin-stimulated mice and the untreated controls. In the present study, we show that it is possible to stimulate tumor cells in xenografts by EGF and thus, enhance cell proliferation, resulting in a higher tumor growth compared to the untreated control group. In our future investigations, we plan to include a higher number of mice, an adjustment of the EGF dosage and cell subanalysis, considering the heterogeneity of SCCHN tumors.
KW  - squamous cell carcinoma of head and neck
KW  - epidermal growth factor
KW  - serotonin
KW  - tumor growth in xenografts
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/29868
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-298685
SN  - 1791-2431
SN  - 1021-335X
N1  - Copyright © 2012, Spandidos Publications. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
VL  - 28
IS  - 3
SP  - 785
EP  - 790
PB  - Spandidos Publ.
CY  - Athens
ER  -