TY  - JOUR
A1  - Jacobs, Benedikt
A1  - Gebel, Veronika
A1  - Heger, Lukas
A1  - Grèze, Victoria
A1  - Schild, Hansjörg
A1  - Dudziak, Diana
A1  - Ullrich, Evelyn
T1  - Characterization and manipulation of the crosstalk between dendritic and natural killer cells within the tumor microenvironment
T2  - Frontiers in immunology
N2  - Cellular therapy has entered the daily clinical life with the approval of CAR T cell therapeutics and dendritic cell (DCs) vaccines in the US and the EU. In addition, numerous other adoptive cellular products, including natural killer (NK) cells, are currently evaluated in early phase I/ II clinical trials for the treatment of cancer patients. Despite these promising accomplishments, various challenges remain to be mastered in order to ensure sustained therapeutic success. These include the identification of strategies by which tumor cells escape the immune system or establish an immunosuppressive tumor microenvironment (TME). As part of the innate immune system, DCs and NK cells are both present within the TME of various tumor entities. While NK cells are well known for their intrinsic anti-tumor activity by their cytotoxicity capacities and the secretion of pro-inflammatory cytokines, the role of DCs within the TME is a double-edged sword as different DC subsets have been described with either tumor-promoting or -inhibiting characteristics. In this review, we will discuss recent findings on the interaction of DCs and NK cells under physiological conditions and within the TME. One focus is the crosstalk of various DC subsets with NK cells and their impact on the progression or inhibition of tumor growth. In addition, we will provide suggestions to overcome the immunosuppressive outcome of the interaction of DCs and NK cells within the TME.
KW  - NK cells
KW  - dendritic cells
KW  - DC-NK cell interaction
KW  - tumor microenvironment
KW  - cellular therapies
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61385
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-613851
SN  - 1664-3224
VL  - 12
IS  - art. 670540
SP  - 1
EP  - 11
PB  - Frontiers Media
CY  - Lausanne
ER  -