TY  - JOUR
A1  - Ebersberger, Ingo
A1  - Simm, Stefan
A1  - Leisegang, Matthias
A1  - Schmitzberger, Peter
A1  - Mirus, Oliver
A1  - Haeseler, Arndt von
A1  - Bohnsack, Markus T.
A1  - Schleiff, Enrico
T1  - The evolution of the ribosome biogenesis pathway from a yeast perspective
T2  - Nucleic Acids Research
N2  - Ribosome biogenesis is fundamental for cellular life, but surprisingly little is known about the underlying pathway. In eukaryotes a comprehensive collection of experimentally verified ribosome biogenesis factors (RBFs) exists only for Saccharomyces cerevisiae. Far less is known for other fungi, animals or plants, and insights are even more limited for archaea. Starting from 255 yeast RBFs, we integrated ortholog searches, domain architecture comparisons and, in part, manual curation to investigate the inventories of RBF candidates in 261 eukaryotes, 26 archaea and 57 bacteria. The resulting phylogenetic profiles reveal the evolutionary ancestry of the yeast pathway. The oldest core comprising 20 RBF lineages dates back to the last universal common ancestor, while the youngest 20 factors are confined to the Saccharomycotina. On this basis, we outline similarities and differences of ribosome biogenesis across contemporary species. Archaea, so far a rather uncharted domain, possess 38 well-supported RBF candidates of which some are known to form functional sub-complexes in yeast. This provides initial evidence that ribosome biogenesis in eukaryotes and archaea follows similar principles. Within eukaryotes, RBF repertoires vary considerably. A comparison of yeast and human reveals that lineage-specific adaptation via RBF exclusion and addition characterizes the evolution of this ancient pathway.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32571
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-325711
SN  - 1362-4962
SN  - 0305-1048
N1  - (c) The Author(s) 2013. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 42
IS  - 3
SP  - 1509
EP  - 1523
PB  - Oxford Univ. Press
CY  - Oxford
ER  -