TY  - JOUR
A1  - Gerçek, Muhammed
A1  - Oldenburg, Olaf
A1  - Gerçek, Mustafa
A1  - Fox, Henrik
A1  - Rudolph, Volker
A1  - Pühler, Thomas
A1  - Omran, Hazem
A1  - Wolf, Lisa Katharina
A1  - Hakim-Meibodi, Kavous
A1  - Zeiher, Andreas M.
A1  - Gummert, Jan
A1  - Dimitriadis, Zisis
T1  - Prevalence of sleep disordered breathing in patients with primary mitral regurgitation undergoing mitral valve surgery
T2  - Journal of clinical medicine
N2  - Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (p = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (p = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (p = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
KW  - mitral valve surgery
KW  - sleep disordered breathing
KW  - mitral regurgitation
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62338
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-623382
SN  - 2077-0383
N1  - The study was supported by the Medical Faculty, Ruhr-Universität Bochum, Germany(FoRUM programme F811-14).
VL  - 10
IS  - 9, art. 2039
SP  - 1
EP  - 9
PB  - MDPI
CY  - Basel
ER  -