TY  - JOUR
A1  - Ottomana, Angela Maria
A1  - Presta, Martina
A1  - O'Leary, Aet
A1  - Sullivan, Mairéad
A1  - Pisa, Edoardo
A1  - Laviola, Giovanni
A1  - Glennon, Jeffrey C.
A1  - Zoratto, Francesca
A1  - Slattery, David A.
A1  - Macrì, Simone
T1  - A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory
T2  - Neuroscience and biobehavioral reviews
N2  - Highlights
• Hyperglycaemia, in rodents, is consistently associated with cognitive impairments.
• The strength of this association is supported by the heterogeneity of the studies.
• The study of the role of insulin on cognition is mainly limited to spatial memory.
• Preclinical studies on the role of insulin signalling on cognition are male biased.
Abstract
Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk factor for the development of mental disorders like Alzheimer’s disease and obsessive-compulsive disorder. While insulin-related somatic and mental disorders are often comorbid, the fundamental mechanisms underlying this association are still elusive. Studies conducted in rodent models appear well suited to help decipher these mechanisms. Specifically, these models are apt to prospective studies in which causative mechanisms can be manipulated via multiple tools (e.g., genetically engineered models and environmental interventions), and experimentally dissociated to control for potential confounding factors. Here, we provide a narrative synthesis of preclinical studies investigating the association between hyperglycaemia – as a proxy of insulin-related metabolic dysfunctions – and impairments in working and spatial memory, and attention. Ultimately, this review will advance our knowledge on the role of glucose metabolism in the comorbidity between somatic and mental illnesses.
KW  - Insulin signalling
KW  - Mental health
KW  - Comorbidity
KW  - Animal models
KW  - Systematic review
Y1  - 2023
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83396
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-833967
SN  - 0149-7634
VL  - 155
IS  - 105435
PB  - Elsevier
CY  - Amsterdam
ER  -