TY  - JOUR
A1  - Fulda, Simone
T1  - Targeting apoptosis signaling in pancreatic cancer
T2  - Cancers
N2  - The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. Additionally, defective apoptosis signaling is the underlying cause of failure to respond to current treatment approaches, since therapy-mediated antitumor activity requires the intactness of apoptosis signaling pathways in cancer cells. Thus, the elucidation of defects in the regulation of apoptosis in pancreatic carcinoma can result in the identification of novel targets for therapeutic interference and for exploitation for cancer drug discovery. Keywords: apoptosis; pancreatic cancer; TRAIL; IAPs; mitochondria
KW  - apoptosis
KW  - pancreatic cancer
KW  - TRAIL
KW  - IAPs
KW  - mitochondria
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/22362
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-100343
SN  - 2072-6694
N1  - © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
VL  - 3
IS  - 1
SP  - 241
EP  - 251
PB  - MDPI
CY  - Basel
ER  -