TY  - JOUR
A1  - Akram, Mohd
A1  - Dietl, Andreas
A1  - Mersdorf, Ulrike
A1  - Prinz, Simone
A1  - Maalcke, Wouter J.
A1  - Keltjens, Jan
A1  - Ferousi, Christina
A1  - Almeida, Naomi M. de
A1  - Reimann, Joachim
A1  - Kartal, Boran
A1  - Jetten, Michael S. M.
A1  - Parey, Kristian Kurt
A1  - Barends, Thomas R. M.
T1  - A 192-heme electron transfer network in the hydrazine dehydrogenase complex
T2  - Science advances
N2  - Anaerobic ammonium oxidation (anammox) is a major process in the biogeochemical nitrogen cycle in which nitrite and ammonium are converted to dinitrogen gas and water through the highly reactive intermediate hydrazine. So far, it is unknown how anammox organisms convert the toxic hydrazine into nitrogen and harvest the extremely low potential electrons (−750 mV) released in this process. We report the crystal structure and cryo electron microscopy structures of the responsible enzyme, hydrazine dehydrogenase, which is a 1.7 MDa multiprotein complex containing an extended electron transfer network of 192 heme groups spanning the entire complex. This unique molecular arrangement suggests a way in which the protein stores and releases the electrons obtained from hydrazine conversion, the final step in the globally important anammox process.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50070
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-500704
SN  - 2375-2548
N1  - Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
VL  - 5
IS  - 4, eaav4310
SP  - 1
EP  - 7
PB  - Assoc.
CY  - Washington, DC [u. a.]
ER  -