TY - JOUR A1 - González-González, Ana I. A1 - Schmucker, Christine A1 - Nothacker, Julia A1 - Nury, Edris A1 - Dinh, Truc Sophia A1 - Brückle, Maria-Sophie A1 - Blom, Jeanet Wilhelmina A1 - Akker, Marjan van den A1 - Röttger, Kristian A1 - Wegwarth, Odette A1 - Hoffmann, Tammy A1 - Gerlach, Ferdinand M. A1 - Straus, Sharon E. A1 - Meerpohl, Jörg J. A1 - Muth, Christiane T1 - End-of-life care preferences of older patients with multimorbidity: a mixed methods systematic review T2 - Journal of clinical medicine N2 - Unpredictable disease trajectories make early clarification of end-of-life (EoL) care preferences in older patients with multimorbidity advisable. This mixed methods systematic review synthesizes studies and assesses such preferences. Two independent reviewers screened title/abstracts/full texts in seven databases, extracted data and used the Mixed Methods Appraisal Tool to assess risk of bias (RoB). We synthesized findings from 22 studies (3243 patients) narratively and, where possible, quantitatively. Nineteen studies assessed willingness to receive life-sustaining treatments (LSTs), six, the preferred place of care, and eight, preferences regarding shared decision-making processes. When unspecified, 21% of patients in four studies preferred any LST option. In three studies, fewer patients chose LST when faced with death and deteriorating health, and more when treatment promised life extension. In 13 studies, 67% and 48% of patients respectively were willing to receive cardiopulmonary resuscitation and mechanical ventilation, but willingness decreased with deteriorating health. Further, 52% of patients from three studies wished to die at home. Seven studies showed that unless incapacitated, most patients prefer to decide on their EoL care themselves. High non-response rates meant RoB was high in most studies. Knowledge of EoL care preferences of older patients with multimorbidity increases the chance such care will be provided. KW - end of life care KW - patient preferences KW - multimorbidity KW - elderly KW - patient centered care Y1 - 2020 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/57220 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-572208 SN - 2077-0383 VL - 10.2021 IS - Article 91 PB - MDPI CY - Basel ER -