TY  - JOUR
A1  - Rutz, Jochen
A1  - Benchellal, Aicha
A1  - Kassabra, Wajdi
A1  - Maxeiner, Sebastian
A1  - Bernd, August
A1  - Kippenberger, Stefan
A1  - Zöller, Nadja Nicole
A1  - Chun, Felix
A1  - Jüngel, Eva
A1  - Blaheta, Roman A.
T1  - Growth, proliferation and metastasis of prostate cancer cells is blocked by low-dose curcumin in combination with light irradiation
T2  - International journal of molecular sciences
N2  - Although anti-cancer properties of the natural compound curcumin have been reported, low absorption and rapid metabolisation limit clinical use. The present study investigated whether irradiation with visible light may enhance the inhibitory effects of low-dosed curcumin on prostate cancer cell growth, proliferation, and metastasis in vitro. DU145 and PC3 cells were incubated with low-dosed curcumin (0.1–0.4 µg/mL) and subsequently irradiated with 1.65 J/cm2 visible light for 5 min. Controls remained untreated and/or non-irradiated. Cell growth, proliferation, apoptosis, adhesion, and chemotaxis were evaluated, as was cell cycle regulating protein expression (CDK, Cyclins), and integrins of the α- and β-family. Curcumin or light alone did not cause any significant effects on tumor growth, proliferation, or metastasis. However, curcumin combined with light irradiation significantly suppressed tumor growth, adhesion, and migration. Phosphorylation of CDK1 decreased and expression of the counter-receptors cyclin A and B was diminished. Integrin α and β subtypes were also reduced, compared to controls. Irradiation distinctly enhances the anti-tumor potential of curcumin in vitro and may hold promise in treating prostate cancer.
KW  - curcumin
KW  - light irradiation
KW  - prostate cancer
KW  - growth
KW  - proliferation
KW  - metastasis
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63513
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635133
SN  - 1422-0067
N1  - This research was funded by the Brigitta & Norbert Muth Stiftung, Wiesbaden, Germany.
VL  - 22
IS  - 18, art. 9966
SP  - 1
EP  - 16
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -