TY  - JOUR
A1  - Tegeder, Irmgard
T1  - Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries
T2  - Data in Brief
N2  - Progranulin deficiency in humans is associated with neurodegeneration. Its mechanisms are not yet fully understood. We performed a Yeast-2-Hybrid screen using human full-length progranulin as bait to assess the interactions of progranulin. Progranulin was screened against human fetal brain and human bone marrow libraries using the standard Matchmaker technology (Clontech). This article contains the full Y2H data table, including blast results and sequences, a sorted table according to selection criteria for likely positive, putatively positive, likely false and false preys, and tables showing the gene ontology terms associated with the likely and putative preys of the brain and bone marrow libraries. The interactions with autophagy proteins were confirmed and functionally analyzed in "Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy" (C. Altmann, S. Hardt, C. Fischer, J. Heidler, H.Y. Lim, A. Haussler, B. Albuquerque, B. Zimmer, C. Moser, C. Behrends, F. Koentgen, I. Wittig, M.H. Schmidt, A.M. Clement, T. Deller, I. Tegeder, 2016).
KW  - Yeast-2-Hybrid
KW  - Protein interactions
KW  - Gene ontology
KW  - Progranulin
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/77244
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-772447
SN  - 2352-3409
VL  - 9
SP  - 1060
EP  - 1062
PB  - Elsevier
CY  - Amsterdam
ER  -