TY  - JOUR
A1  - Krüger, Caroline
A1  - Schäfer, Ingmar
A1  - Bussche, Hendrik van den
A1  - Bickel, Horst
A1  - Dreischulte, Tobias
A1  - Fuchs, Angela
A1  - König, Hans-Helmut
A1  - Maier, Wolfgang
A1  - Mergenthal, Karola
A1  - Riedel-Heller, Steffi Gerlinde
A1  - Schön, Gerhard
A1  - Weyerer, Siegfried
A1  - Wiese, Birgitt
A1  - Renteln-Kruse, Wolfgang von
A1  - Langebrake, Claudia
A1  - Scherer, Martin
T1  - Comparison of FORTA, PRISCUS and EU(7)-PIM lists on identifying potentially inappropriate medication and its impact on cognitive function in multimorbid elderly german people in primary care: a multicentre observational study
T2  - BMJ open
N2  - Objectives Our study aimed to assess the frequency of potentially inappropriate medication (PIM) use (according to three PIM lists) and to examine the association between PIM use and cognitive function among participants in the MultiCare cohort. Design MultiCare is conducted as a longitudinal, multicentre, observational cohort study. Setting The MultiCare study is located in eight different study centres in Germany. Participants 3189 patients (59.3% female). Primary and secondary outcome measures The study had a cross-sectional design using baseline data from the German MultiCare study. Prescribed and over-the-counter drugs were classified using FORTA (Fit fOR The Aged), PRISCUS (Latin for ‘time-honoured’) and EU(7)-PIM lists. A mixed-effect multivariate linear regression was performed to calculate the association between PIM use patients’ cognitive function (measured with (LDST)). Results Patients (3189) used 2152 FORTA PIM (mean 0.9±1.03 per patient), 936 PRISCUS PIM (0.3±0.58) and 4311 EU(7)-PIM (1.4±1.29). The most common FORTA PIM was phenprocoumon (13.8%); the most prevalent PRISCUS PIM was amitriptyline (2.8%); the most common EU(7)-PIM was omeprazole (14.0%). The lists rate PIM differently, with an overall overlap of 6.6%. Increasing use of PIM is significantly associated with reduced cognitive function that was detected with a correlation coefficient of −0.60 for FORTA PIM (p=0.002), −0.72 for PRISCUS PIM (p=0.025) and −0.44 for EU(7)-PIM (p=0.005). Conclusion We identified PIM using FORTA, PRISCUS and EU(7)-PIM lists differently and found that PIM use is associated with cognitive impairment according to LDST, whereby the FORTA list best explained cognitive decline for the German population. These findings are consistent with a negative impact of PIM use on multimorbid elderly patient outcomes.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63019
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-630190
SN  - 2044-6055
N1  - The study was funded by the German Federal Ministry of Education and Research (grant numbers 01ET0725-31 and 01ET1006A-K). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
VL  - 11
IS  - 9, art. e050344
SP  - 1
EP  - 10
PB  - BMJ Publishing Group
CY  - London
ER  -