TY  - JOUR
A1  - Hellwig, Nils
A1  - Martin, Janosch
A1  - Morgner, Nina
T1  - LILBID-MS: using lasers to shed light on biomolecular architectures
T2  - Biochemical Society transactions
N2  - Structural Biology has moved beyond the aim of simply identifying the components of a cellular subsystem towards analysing the dynamics and interactions of multiple players within a cell. This focal shift comes with additional requirements for the analytical tools used to investigate these systems of increased size and complexity, such as Native Mass Spectrometry, which has always been an important tool for structural biology. Scientific advance and recent developments, such as new ways to mimic a cell membrane for a membrane protein, have caused established methods to struggle to keep up with the increased demands. In this review, we summarize the possibilities, which Laser Induced Liquid Bead Ion Desorption (LILBID) mass spectrometry offers with regard to the challenges of modern structural biology, like increasingly complex sample composition, novel membrane mimics and advanced structural analysis, including next neighbor relations and the dynamics of complex formation.
KW  - ionization
KW  - LILBID-MS
KW  - mass spectrometry
KW  - membrane mimics
KW  - membrane proteins
KW  - Instrumentation & Devices
KW  - Molecular Interactions
KW  - Structural Biology
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62896
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-628960
SN  - 1470-8752
N1  - The Open Access Publication of this article was made possible by the GRADE center iQbio.
VL  - 50
IS  - 3
SP  - 1057
EP  - 1067
PB  - Portland Press
CY  - London
ER  -