TY  - JOUR
A1  - Schmidt, Hannes
A1  - Böttcher, Alexandra
A1  - Groß, Tilman
A1  - Schmidtko, Achim
T1  - cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood
T2  - British journal of pharmacology
N2  - Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating evidence suggests that cGMP regulates different cellular processes from embryonic development through to adulthood. During embryonic development, a cGMP-dependent signalling cascade in the trunk sensory system is essential for axon bifurcation, a specific form of branching of somatosensory axons. In adulthood, various cGMP signalling pathways in distinct cell populations of sensory neurons and dorsal horn neurons in the spinal cord play an important role in the processing of pain and itch. Some of the involved enzymes might serve as a target for future therapies. In this review, we summarise the knowledge regarding cGMP-dependent signalling pathways in dorsal root ganglia and the spinal cord during embryonic development and adulthood, and the potential of targeting these pathways.


LINKED ARTICLES

This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issuetoc
KW  - axon bifurcation
KW  - axon branching
KW  - cGMP signalling
KW  - dorsal root ganglia
KW  - itch
KW  - pain
KW  - somatosensory system
KW  - spinal cord
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72333
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-723333
SN  - 1476-5381
N1  - The authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) with Research Unit FOR 2060 project SCHM 2371/1 to Hannes Schmidt, project 335549539/GRK2381 to Alexandra Böttcher and Hannes Schmidt and Research Unit FOR 2060 project SCHM 2629/3-1 and project SCHM 2629/4-1 to Achim Schmidtko. This article is based in part upon work from the DFG-funded Research Unit FOR 2060.
VL  - 179
IS  - 11
SP  - 2361
EP  - 2377
PB  - Wiley
CY  - Malden, MA
ER  -