TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Sheldrick, William S.
A1  - Lambrecht, Günter
A1  - Moser, Ulrich
A1  - Mutschler, Ernst
T1  - Sila-Pharmaka, 31. Mitt. [1]. Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
T1  - Sila-Pharmaca, 31 th communication [1]. Synthesis, structure, and pharmacological properties of diphenyl(2-piperidinoethoxymethyl)silanol and its carbon analogue
T2  - Zeitschrift für Naturforschung, B
N2  - In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
KW  - Sila-Substitution
KW  - Crystal and Molecular Structure
KW  - Antimuscarinic and Papaverine-Like Activity
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/71973
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-719732
SN  - 1865-7117
SN  - 0932-0776
VL  - 38.1983
IS  - 6
SP  - 738
EP  - 746
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -