TY  - JOUR
A1  - Raue, Rebecca
A1  - Frank, Ann-Christin
A1  - Syed, Shahzad Nawaz
A1  - Brüne, Bernhard
T1  - Therapeutic targeting of microRNAs in the tumor microenvironment
T2  - International journal of molecular sciences
N2  - The tumor-microenvironment (TME) is an amalgamation of various factors derived from malignant cells and infiltrating host cells, including cells of the immune system. One of the important factors of the TME is microRNAs (miRs) that regulate target gene expression at a post transcriptional level. MiRs have been found to be dysregulated in tumor as well as in stromal cells and they emerged as important regulators of tumorigenesis. In fact, miRs regulate almost all hallmarks of cancer, thus making them attractive tools and targets for novel anti-tumoral treatment strategies. Tumor to stroma cell cross-propagation of miRs to regulate protumoral functions has been a salient feature of the TME. MiRs can either act as tumor suppressors or oncogenes (oncomiRs) and both miR mimics as well as miR inhibitors (antimiRs) have been used in preclinical trials to alter cancer and stromal cell phenotypes. Owing to their cascading ability to regulate upstream target genes and their chemical nature, which allows specific pharmacological targeting, miRs are attractive targets for anti-tumor therapy. In this review, we cover a recent update on our understanding of dysregulated miRs in the TME and provide an overview of how these miRs are involved in current cancer-therapeutic approaches from bench to bedside.
KW  - breast cancer
KW  - inflammation
KW  - macrophage
KW  - microRNA
KW  - RNA therapy
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/60990
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-609906
SN  - 1422-0067
VL  - 22
IS  - 4, art. 2210
SP  - 1
EP  - 37
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -